Emerging research suggests that creatine supplementation may significantly reduce symptoms of depression, particularly in women. Some studies have reported up to a 63% reduction in depression scores among participants.

Notably, improvements have been observed within 1–2 weeks, which is faster than the typical onset of many traditional antidepressants. 

Creatine is believed to support brain energy metabolism by increasing the availability of cellular energy in the form of ATP. 

This enhanced energy support may help improve mood, cognitive function, and overall emotional resilience.