A study published in Oncotarget (2016) investigated the effects of aqueous dandelion root extract (DRE) on colorectal cancer cells. Researchers found that DRE selectively induced programmed cell death in more than 95% of colon cancer cells within 48 hours, regardless of their p53 status, while showing no toxicity toward non-cancerous cells in laboratory models. Gene expression analysis revealed that multiple cell death signaling pathways were activated, suggesting a broad mechanism of action against cancer cells.The anti-cancer effects were further supported by in vivo findings, where oral administration of dandelion root extract reduced the growth of human colon cancer tumors in xenograft mouse models by more than 90%. Phytochemical analysis showed that the extract contains several bioactive compounds, including α-amyrin, β-amyrin, lupeol, and taraxasterol, which may contribute to its ability to target multiple vulnerabilities in cancer cells and potentially reduce drug resistance.PMID: 27564258 PMCID: PMC5341965
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