תזונה מיטבית מונעת דיכאון
YAAKOV WAKSMAN ·
תזונה מיטבית מונעת דיכאון
Key ingredients of the active dietary supplement included: 2 g of l-tryptophan (Apotex, two 1gram tablets) 10 g of l-tyrosine (Natural Factors, twenty 500 mg tablets), blueberry juice and blueberry extract (Vitablue). On the night of day 3, the morning and evening of day 4, and morning of day 5 postpartum, participants ingested one pouch of active extract or placebo mixed with blueberry juice or placebo. The blueberry juice, blueberry extract and corresponding placebo were prepared by NSF. The placebo pouches matching the blueberry extract contain Shade grape blue powder. The placebo drink was blue through natural colouring with blueberry taste through natural flavouring, but had negligible antioxidant properties and similar sugar level to the active drink. Placebo pills were empty hard gelatin capsules from Capsugel and Lactose monohydrate from Galenova, identical in appearance to encapsulated tryptophan and tyrosine, all prepared by the CAMH pharmacy. Active beverage (weight 369.55 g) included blueberry juice concentrate (9.99%, Milne), filtered water (79.5%, National Sanitation Foundation), natural blueberry flavour (0.75%, Bell Flavours), granulated sugar (5.99%, Caldic) and citric acid (0.1%, Caldic). The pouch, which was added to the beverage just prior to time of ingestion, included Vitablue North American Blueberry Extract (0.55%, Futureceuticals) and granulated sugar (3.12%, Caldic). Placebo beverage (weight 362.55 g) included natural blueberry flavour (1%, Bell Flavours), filtered water (89.11%, National Sanitation Foundation), granulated sugar (5.71%, Caldic), citric acid (0.2%, Caldic) and Shade Bordeaux (0.25%, GNT). The pouch, which was added to the beverage just prior to the time of ingestion included shade grape blue powder (0.28%, GNT) and granulated sugar (3.46%, Caldic). Volumes and ingredient proportions of beverages varied by less than 5%. Taste was identical across the two products as assessed by the National Sanitation Foundation and study personnel at CAMH. ORAC (Oxygen Radical Absorbance Capacity) values of study product from the same batch were assessed prior to use, at 6 months and at 10 months whereupon a new batch was given to verify consistency across batches as well as in comparison to the previous open trial.19 Participants were allowed to breastfeed. Phone call reminders were given for the first three doses, and the last dose (inclusive of tyrosine or placebo) was supervised by study staff. Participants were also asked about completion of each previous dose at these timepoints to verify adherence.
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